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Transitional cell carcinoma (TCC) is a type of cancer that originates in the kidney, bladder or ureter. It is the most common type of bladder cancer.
It arises from the transitional epithelium lining found in these organs.[1]
When the term “urothelial” is used, it specifically refers to a carcinoma of the urothelium. However, transitional cell carcinoma can also be associated with the prostate.[2][3]
The most common site of TCC metastasis outside the pelvis is bone (35%); of these bone metastases, 40% are in the spine.[4]
Transitional refers to the histological subtype of the cancerous cells as seen under a microscope.
It is associated with increased incidence in smokers and those who drink excessive alcohol as well HNPCC.
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