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Paraneoplastic cerebellar degeneration is a paraneoplastic phenomenon associated with lung, ovarian, breast, and other cancers.
It is believed to be due to an autoimmune reaction targeted against components of the central nervous system (specifically Purkinje cells and large brain stem nuclei). It is thought to be caused by an anti-neuronal Antibody known as anti-Yo.
It typically presents as a subacute progressive cerebellar ataxia, both truncal and appendicular.
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