Hyperhomocysteinemia

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Hyperhomocysteinemia is a medical condition characterized by an abnormally large level of homocysteine in the blood.

As a consequence of the biochemical reactions in which homocysteine is involved, deficiencies of the vitamins folic acid, pyridoxine (B6), or B12 can lead to high homocysteine levels.[1] Supplementation with pyridoxine, folic acid, B12 or trimethylglycine (betaine) reduces the concentration of homocysteine in the bloodstream.[2]

Normal fasting homocysteine plasma levels are between 5,0 and 15,9 mmol/l.

Hyperhomocysteinemia is a risk factor for coronary artery disease and in cases of young myocardial infarction the level is found to be elevated.

MTHFR (A1298C) DNA Gene mutation has been associated with an increased risk for Hyperhomocysteinemia. MTHFR is involved in the methylation of homocysteine to methionine. Individuals with MTHFR gene mutations that reduce enzyme activity, may develop hyperhomocysteinemia and thus be at risk for vascular disease. There are holistic treatments.

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