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Cyclic neutropenia (or cyclical neutropenia) is a form of neutropenia which tends to occur every three weeks and lasting three to six days at a time due to changing rates of cell production by the bone marrow.
It is often present among several members of the same family. Treatment includes G-CSF and usually improves after puberty.
Cyclic neutropenia is the result of autosomal dominantly inherited mutations in ELA2, the gene encoding neutrophil elastase.[1]
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