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Capillary leak syndrome (sometimes systemic capillary leak syndrome or Clarkson syndrome) is a rare medical condition where the number and size of the pores in the capillaries are increased which leads to a leakage of fluid from the blood to the interstitial fluid, resulting in dangerously low blood pressure (hypotension), edema and multiple organ failure due to limited perfusion.
The syndrome was first described by Clarkson in 1960.[1]
Episodes of:[citation needed]
The episode usually consists of two phases:[citation needed]
Mortality is reported in 21% of the 57 cases described.[citation needed] However, better management of this condition has recently led to lower mortality. A few prophylactic treatments have been tried with variable results, principally terbutaline and theophyllin. Patients need to be monitored for monoclonal gammopathy since it may turn into multiple myeloma.[citation needed]
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