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In medicine, mixed connective tissue disease, commonly abbreviated as MCTD, is an autoimmune disease, in which the body’s defense system attacks itself. It is also known as Sharp syndrome.
MCTD combines features of polymyositis, systemic lupus erythematosus, scleroderma, and dermatomyositis,[1] and is thus considered an overlap syndrome.
MCTD commonly causes:
Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody.[2]
It has been associated with HLA-DR4.[3]
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