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Loin pain hematuria syndrome, also LPHS, is the combination of unilateral or bilateral flank pain and microscopic or macroscopic amounts of blood in the urine that is otherwise unexplained.[1]
LPHS is considered a diagnosis of exclusion as hematuria (blood in the urine) and flank pain can result from a number of causes.
LPHS has considerable overlap with chronic pelvic pain and often, like chronic pelvic pain, has a significant psychiatric component, with a high co-morbidity of somatoform disorder.[2]
A thin glomerular basement membrane, as in thin basement membrane disease, is proposed to be the characteristic finding on renal biopsy,[3] but not part of the syndrome definition.
The condition is very rare and predominately affects females. Worldwide, only several hundred cases have been reported.
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