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Hypogammaglobulinemia is a type of immune disorder characterized by a reduction in all types of gamma globulins.[1]
It is distinguished from dysgammaglobulinemia, which is a reduction in some types of gamma globulins, but not others.[2][3]
It is largely synonymous with “agammaglobulinemia”. When this term is used (as in “X-linked agammaglobulinemia”) it implies that gamma globulins are not merely reduced, but completely absent. Modern assays have allowed most agammaglobulinemias to be more precisely defined as hypogammaglobulinemias,[4] but the distinction is not usually clinically relevant.
Hypogammaglobulinemia is a characteristic of common variable immunodeficiency.[5]
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