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Gonadal dysgenesis generally refers to a condition where gonadal development is atypical, often only presenting streaks of connective tissue: so-called streak gonads.
This condition will occur if there is an absence of Mullerian inhibiting factor with concomitant absence of testosterone. The absence of testosterone will result in the Wolffian ducts’ regression; normal male internal reproductive tracts will not develop. The absence of Mullerian inhibiting factor will allow for the Mullerian ducts to differentiate into the oviducts and uterus. In sum, this individual will be genotypically male (i.e., XY), yet will possess female-like internal and external reproductive characteristics.
The condition may be due to:
It is one of the causes of intersexuality, because the genitalia are determined to be neither exclusively male nor female.
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