Read more about this disease, some with Classification – Types – Signs and symptoms – Genetics – Pathophysiology – Diagnosis – Screening – Prevention – Treatment and management – Cures and much more, some including pictures and video when available.
Gluten-sensitive enteropathy has a wide variety of associated conditions, however the key symptoms are typically restricted to the bowel and associated tissues. These include bowel disorders (diarrhoea, constipation, irritable bowel), eosinophilic gastroenteritis and increase with coeliac disease (CD) severity. With some early onset and a large percentage of late onset disease, other disorders appear prior to the celiac diagnosis [1] or allergic-like responses (IgE or IgA, IgG) markedly increased in GSE many which persist on a strict GF diet, and thus become independent of coeliac disease after triggering. For example autoimmune thyroiditis is a common finding with GSE.
However, GSE’s association with disease is not limited to common autoimmune diseases, coeliac disease has been found at increased frequency on followup to many autoimmune diseases, some rare. Complex causes of autoimmune diseases often demonstrates only weak association with celiac disease. The frequency of GSE is typically around 0.3 to 1% and lifelong risk of this form of gluten sensitivity increases in age, possibly as high as 2% for people over 60 years of age.[2] This coincides with the period in life when late-onset autoimmune diseases also rise in frequency.
Genetic studies indicate that coeliac disease genetically links to loci shared by linkage with other autoimmune diseases.[3] These linkages may be coincidental with how symptomatic disease is selected from a largely assymptomatic population.
Avitaminosis. Avitaminosis caused by Maladsorption in GSE can results in decline of fat soluble vitamins and vitamin B, as well as maladsorption of essential fatty acids. This can cause a wide variety of secondary problems. hypocalcinemia is also associated with GSE. [4] In treated GSE, the restrictions on diet as well as reduced absorption as a result of prolonged damage may result in post treatment deficiencies.[5]
Mineral deficiencies. GSE is associated with the following mineral deficiencies:
Blood factors
Megaloblastic anemia (MA) is associated with GSE and is believed to be the result of B-12 and folate deficiency. [23] In GSE, is appears to be associated with the IgA-less phenotype.[24]. Unlike other forms of megaloblastic anemia, GSEA MA is not a form of autoimmune gastritis.[25]
[tubepress mode=’tag’, tagValue=’Gluten-sensitive enteropathy associated conditions’]