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Endocardial fibroelastosis (EFE) is a rare heart disorder usually associated with children two years old and younger.[1]
It should not be confused with endomyocardial fibrosis.
It is characterized by a thickening within the muscular lining of the heart chambers (the endocardium) due to an increase in the amount of supporting connective tissue and elastic fibers.
It is an uncommon cause of unexplained heart failure in infants and children.
It is one component of HEC syndrome.[citation needed]
EFE has two distinct genetic forms, each having a different mode of inheritance. An x-linked recessive form,[2] and an autosomal recessive form[3] have both been observed.
There is also some evidence that viral infection may play a role as a cause or trigger.[4]
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